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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often focused on practical aspects of the research design, like recruitment and consent, adherence, and the use of standard equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which used various investigators and included participants from various geographical areas. This type of heterogeneity is essential for practical trials to be valid, and it also helps to reduce the chance of bias in the results. A high degree of heterogeneity, however could cause issues with the design of the trial.

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Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. They are typically requested by practitioners and policymakers to help inform their decisions. They also provide a useful way to identify the causality between an intervention and its outcomes. They should, however, not, be used to replace explanatory studies.

The pragmatism concept is controversial, and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which validate a physiological or clinical hypothesis as well as pragmatic trials, which guide policy and practice decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool attempted to define the traits of a pragmatic research study that includes recruitment, design, 프라그마틱 슬롯 환수율 delivery of the intervention and follow-up.

There is a growing increase in the number pragmatic trials that are published. A recent Medline search using the keywords naturalistic and pragmatic, limited to controlled trials randomized to control (RCTs), yielded 34 articles, as shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to remember that the majority of studies were conducted in primary care settings.